The AI industry entered 2025 with strong momentum. According to a TechCrunch count, 49 startups raised funding rounds worth $100 million or more in 2024. Within that group, three companies raised more than one mega-round, and seven companies raised rounds that were $1 billion or larger.
The industry did not slow down in 2025. While fewer companies raised rounds larger than $1 billion, four companies achieved this—with Anthropic raising two rounds over $1 billion. Significantly more companies raised multiple rounds compared to 2024, with eight doing so versus the previous year’s three.
Early signs point to another strong year in 2026. Elon Musk’s xAI announced a $20 billion Series E round, and Sam Altman’s brain-computer interface startup Merge Labs raised a $250 million seed round with OpenAI as the lead investor in the first few weeks. Of course, it is still early, and the industry will be watched to see if the momentum continues.
Here is a list of U.S. AI companies that raised $100 million or more in 2025, organized by month.
In December, Austin-based Mythic raised a $125 million venture round for power-efficient AI compute. Chai Discovery announced a $130 million Series B for AI models in biotech. Generative media platform Fal raised a $140 million Series D. Unconventional AI announced a $475 million seed round. Boston-based 7AI raised a $130 million Series A for cybersecurity AI agents.
November saw Genspark raise a $275 million Series B for its AI workspace. Luma AI raised $900 million in a Series C for photo and video creation models. Anysphere, maker of Cursor, raised $2.3 billion. Parallel raised a $100 million Series A for AI agent infrastructure. Hippocratic AI raised a $126 million Series C for healthcare agents.
In October, Fireworks AI raised a $250 million Series C for building applications with open-source models. Enterprise AI startup Uniphore raised a $260 million Series F. Voice AI company Sesame raised a $250 million Series B. OpenEvidence raised a $200 million Series C for a medical AI chatbot. Lila Sciences raised a $350 million Series A for a science platform. Reflection AI raised a $2 billion Series B. EvenUp raised a $150 million Series E for AI in personal injury law.
September featured Periodic Labs with a $300 million seed round for an AI scientist. Cerebras Systems raised a $1.1 billion Series G for AI infrastructure. Modular announced a $250 million funding round. Distyl AI raised a $175 million Series B for enterprise software. Upscale AI raised a $100 million seed round for infrastructure. Groq raised a $750 million Series D-3 for AI inference. Invisible Technologies raised $100 million for AI training. Cognition AI raised a $400 million Series C for its coding agent. Baseten raised a $150 million Series D for infrastructure. Sierra raised $350 million for customer service AI agents. You.com raised a $100 million Series C for AI search. Anthropic raised a $13 billion Series F.
During August, EliseAI raised $250 million for healthcare and housing automation. Decart raised $100 million for AI research.
In July, Fal raised a $125 million Series C for generative media. Ambience Healthcare raised a $243 million Series C for a healthcare operating system. Reka AI raised $110 million for multimodal AI platforms. Thinking Machines Lab raised $2 billion in a seed round. OpenEvidence raised $210 million for clinician search tools. Harmonic raised a $100 million Series B for mathematical reasoning.
June included Abridge raising a $300 million Series E for medical transcription. Harvey raised a $300 million round for legal AI tools. Tennr raised a $101 million Series C for healthcare referrals. Glean raised a $150 million Series F for enterprise search. Anysphere raised a $900 million Series C for its AI coding tool.
May featured Snorkel AI raising a $100 million Series D for data labeling. LMArena raised a $100 million seed round for AI benchmarking. TensorWave raised a $100 million Series A for AI infrastructure.
In April, SandboxAQ closed a $450 million Series E round. Runway raised a $308 million Series D for AI media models.
March was a massive month with OpenAI raising a record $40 billion round. Nexthop AI raised a $110 million Series A for infrastructure. Insilico Medicine raised $110 million for AI drug discovery. Celestial AI raised a $250 million Series C for photonic infrastructure. Lila Sciences raised a $200 million seed round for science superintelligence. Reflection AI raised a $130 million Series A. Turing raised a $111 million Series E for AI coding. Shield AI raised $240 million for defense tech. Anthropic raised a $3.5 billion Series E.
February saw Together AI raise a $305 million Series B for open-source generative AI. Lambda raised a $480 million Series D for AI infrastructure. Abridge raised a $250 million Series D for medical transcription. Eudia raised $105 million in a Series A for legal tech. EnCharge AI raised a $100 million Series B for AI hardware. Harvey raised a $300 million Series D for legal AI.
In January, ElevenLabs raised a $180 million Series C for synthetic voice technology. Hippocratic AI announced a $141 million Series B for healthcare language models.
This report was updated throughout the year to include new deals.